Journal Article PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction

Kato, Masaya  ,  Muromoto, Ryuta  ,  Togi, Sumihito  ,  Iwakami, Masashi  ,  Kitai, Yuichi  ,  Kon, Shigeyuki  ,  Oritani, Kenji  ,  Matsuda, Tadashi

461 ( 2 )  , pp.366 - 371 , 2015-05-29 , Elsevier
The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription-regulatory complexes with a variety of repressor proteins. In the present study, we found that endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells. We also found that PML-mediated suppression of IL-6-induced STAT3 activation by disrupting interactions between STAT3 and HDAC3. These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by interacting with HDAC3. (C) 2015 Elsevier Inc. All rights reserved.

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