Journal Article Biological Response to Nanostructure of Carbon Nanotube/titanium Composite Surfaces

Erika, Nishida  ,  Hirofumi, Miyaji  ,  Junko, Umeda  ,  Katsuyoshi, Kondoh  ,  Hiroko, Takita  ,  Izumi, Kanayama  ,  Saori, Tanaka  ,  Akihito, Kato  ,  Bunshi, Fugetsu  ,  Tsukasa, Akasaka  ,  Masamitsu, Kawanami

7 ( 1 )  , pp.11 - 20 , 2015-06-30 , ナノバイオメディカル学会 , Nano Biomedical Society
Titanium (Ti) is frequently used as a biomaterial in dental and orthopedic implants and in bone fixation devices. Effective modification of the Ti surface plays a crucial role in improving biocompatibility. Carbon nanotubes (CNTs) are among the most interesting nanomaterials due to their unique properties. In this study, we fabricated CNT-Ti composite surfaces by annealing Ti plates covered by different sized CNTs (Nanocyl NC 7000, 9.5 nm diameter and VGCF-H, 150 nm diameter). The properties of these surfaces were examined by scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, raman spectroscopy, contact angle measurement and osteoblast-like cell seeding. In addition, samples were implanted into the subcutaneous tissue of rats. The three-dimensional nanostructures of CNTs and creation of titanium carbide were evident on the Ti surfaces, suggesting that the CNTs were well-anchored onto the Ti plates. CNT modification promoted desirable cell behavior, including cell spreading and proliferation, especially on the Nanocyl-modified surface. Inflammatory response was rarely observed on the Nanocyl surface, but macrophage-like giant cells were frequently observed on the VGCF-H surface. Therefore, the nanomorphology of narrow diameter CNTs provides a CNT-Ti composite surface with good biocompatibility.

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