Thesis or Dissertation Glycomics Approach of Livestock Management Toward the Discovery of Novel Biomarkers Indicating an Environmental Stress

Rehan, Ibrahim Farag Mohammed

Because various stresses strongly influence the food productivity of livestock,biomarkers to indicate unmeasurable environmental stress in domestic farm animals are ofincreasing importance. Thermal comfort is one of the basic principles of dairy cow welfare thatenhances productivity, so that the more attention needs to be placed on the principles of TheWelfare Quality® Assessment protocol, especially in summer and autumn seasons, in order toenhance the performance and production. However, the expression levels of two major sialicacids, notably Neu5Ac and Neu5Gc, in the glycoproteins/glycosphingolipids synthesized bycommon mammalian cells except human cells might be a critical posttranslational modificationindicating drastic changes of the metabolic immune balance as well as seasonal alteration of thetotal serum N-glycan profiles; as an abundant and major class of glycoconjugates in animalserum glycoproteins. Thus, I considered that advent of novel and sensitive serum biomarkersusing glycoblotting combined with MALDI-TOF/MS and DMB-HPLC allowed forcomprehensive N-glycomics of animal model to indicate not only their productivities butsignificant changes in total healthy condition caused by unmeasurable stresses would contributegreatly to the improvement of their management, healthy performance and high-qualityproductivity.
Hokkaido University(北海道大学). 博士(生命科学)

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