Journal Article Synthesis of Diazirine-Based Photoreactive Saccharin Derivatives for the Photoaffinity Labeling of Gustatory Receptors

Wang, Lei  ,  Yoshida, Takuma  ,  Muto, Yasuyuki  ,  Murai, Yuta  ,  Tachrim, Zetryana Puteri  ,  Ishida, Akiko  ,  Nakagawa, Shiori  ,  Sakihama, Yasuko  ,  Hashidoko, Yasuyuki  ,  Masuda, Katsuyoshi  ,  Hatanaka, Yasumaru  ,  Hashimoto, Makoto

(14)  , pp.3129 - 3134 , 2015-05-18 , Wiley-Blackwell
ISSN:1434-193X
Description
Saccharin is one of the most common artificial sweeteners that has a bitter taste at high concentrations. Currently, there are no detailed functional analyses of these gustatory receptors. Therefore, we designed and synthesized photoreactive saccharin derivatives that contain a (trifluoromethyl) diazirinyl moiety at the 5- or 6-position for use as functional analysis tools for photoaffinity labeling.
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/61529/1/70112%28hashimoto%ef%bc%89.pdf

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