学術雑誌論文 Choroidal thickening prior to anterior recurrence in patients with Vogt-Koyanagi-Harada disease

Tagawa, Yoshiaki  ,  Namba, Kenichi  ,  Mizuuchi, Kazuomi  ,  Takemoto, Yuko  ,  Iwata, Daiju  ,  Uno, Tomoe  ,  Fukuhara, Takako  ,  Hirooka, Kiriko  ,  Kitaichi, Nobuyoshi  ,  Ohno, Shigeaki  ,  Ishida, Susumu

100 ( 4 )  , pp.473 - 477 , 2016-04 , BMJ Publishing Group
ISSN:0007-1161
NII書誌ID(NCID):AA00574774
内容記述
Aim: To assess choroidal thickness changes associated with anterior segment recurrences in patients with Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography (EDI-OCT). Methods: EDI-OCT images were obtained periodically from 11 VKH disease patients (22 eyes) who were followed-up due to anterior segment recurrences. Subfoveal choroidal thickness (SCT) values at the following stages were evaluated: (1) during the remission phase, (2) one month before detecting the anterior recurrence, (3) during the anterior recurrence, and (4) after systemic prednisolone (PSL) treatment leading to remission. In comparison with SCT values in remission as baseline, the changing ratios of SCT were statistically analyzed at subsequent three stages. Results: The average of the SCT changing ratios compared to the remission phase significantly increased to 1.45 ± 0.11 during anterior segment recurrences (P=0.00044) lacking any funduscopic signs of posterior involvement. Interestingly, the average SCT ratio one month before detecting the recurrence had already increased to 1.30 ± 0.08 (P=0.002). After the PSL treatment, the ratio of SCT recovered to 0.95 ± 0.03 which was equivalent with the remission level. However, in patients with their remission SCT values less than 240 μm, the SCT ratio did not increase significantly at any time points evaluated. Conclusions: The choroid in eyes with VKH disease thickened in association with the anterior segment recurrence, and this thickening was observed prior to the recurrence. EDI-OCT may be useful for detecting latent choroidal inflammation in VKH disease, whereas it may not for patients with the relatively thin choroid.
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/61501/1/BJOv100p473.pdf

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