Journal Article Applications of CRSIPR/Cas9 in Cancer Research

Yue, Junming  ,  Du, Ziyun  ,  Zhou, Fu-Ming  ,  Dong, Peixin  ,  Pfeffer, Lawrence M

1 ( 1 )  , p.1000103 , 2016-03 , OMICS International
The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research.

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