学術雑誌論文 Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp through interspecies mutualism

Bhuiyan, Mohammad Nazrul Islam  ,  Takai, Ryogo  ,  Mitsuhashi, Shinya  ,  Shigetomi, Kengo  ,  Tanaka, Yasuhiro  ,  Kamagata, Yoichi  ,  Ubukata, Makoto

69 ( 2 )  , pp.97 - 103 , 2015-08-26 , 日本抗生物質学術協議会(Japan Antibiotics Research Association)
ISSN:0021-8820
内容記述
We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A-F for the previously uncultured bacterial strain, Leucobacter sp. ASN212, from a supernatant of 210 l of Sphingopyxis sp. GF9 culture. Growth factors A-F induced significant growth of strain ASN212 at the concentrations of picomolar to nanomolar which would otherwise be unculturable in liquid medium or on agar plate. More interestingly, we found that the growth factors functioned as self-toxic compounds for the growth-factor producing strain GF9 at the picomolar to nanomolar levels. As a variety of bacteria could potentially produce coproporphyrins, our findings suggest that these compounds function as a novel class of signal molecules across a boundary at phylum level in the complex bacterial communities.
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/61410/1/JA69_97-103.pdf

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