Journal Article Multi-institutional retrospective study for the evaluation of ocular function-preservation rates in maxillary sinus squamous cell carcinomas with orbital invasion

Sakashita, Tomohiro  ,  Hayashi, Ryuichi  ,  Homma, Akihiro  ,  Matsuura, Kazuto  ,  Kato, Kengo  ,  Kawabata, Kazuyoshi  ,  Monden, Nobuya  ,  Hasegawa, Yasuhisa  ,  Onitsuka, Tetsuro  ,  Fujimoto, Yasushi  ,  Iwae, Shigemichi  ,  Okami, Kenji  ,  Matsuzuka, Takashi  ,  Yoshino, Kunitoshi  ,  Fujii, Masato

37 ( 4 )  , pp.537 - 542 , 2015-04 , Wiley
Background. This study aimed to evaluate ocular function and survival rates among treatment modalities in patients with maxillary sinus cancer with orbital invasion. Methods. Eighty-seven patients were classified according to the main treatment modality. Ocular function preservation rates and survival rates were evaluated for each therapeutic modality. Results. The 5-year overall survival rate for the en bloc resection, conservative surgery, superselective intra-arterial chemotherapy and radiotherapy (RADPLAT), intra-venous chemoradiotherapy (IV-CRT) was 70%, 35%, 49%, and 31%, respectively. Ocular function preservation rate for each group was 15%, 27%, 30%, and 17%, respectively. In the en bloc resection group, there was no significant difference in the 5-year overall survival rate between patients with orbital exenteration and those without orbital exenteration (72% vs 71%, p=0.9321). Conclusions. The en bloc resection group showed a favorable survival rate, but a low preservation rate. Preservation of orbital contents did not reduce the survival rate.

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