学術雑誌論文 Rapid Evaluation of Fibrinogen Levels Using the CG02N Whole Blood Coagulation Analyzer

Hayakawa, Mineji  ,  Gando, Satoshi  ,  Ono, Yuichi  ,  Mizugaki, Asumi  ,  Katabami, Kenichi  ,  Maekawa, Kunihiko  ,  Miyamoto, Daisuke  ,  Wada, Takeshi  ,  Yanagida, Yuichiro  ,  Sawamura, Atsushi

41 ( 3 )  , pp.267 - 271 , 2015-04 , Thieme
ISSN:1098-9064
内容記述
Rapid evaluation of fibrinogen (Fbg) levels is essential for maintaining homeostasis in patients with massive bleeding during severe trauma and major surgery. This study evaluated the accuracy of fibrinogen levels measured by the CG02N whole blood coagulation analyzer (A&amp;T Corporation, Kanagawa, Japan) using heparinized blood drawn for blood gas analysis (whole blood-Fbg). A total of 100 matched pairs of heparinized blood samples and citrated blood samples were simultaneously collected from patients in the intensive care unit. Whole blood-Fbg results were compared with those of citrated plasma (standard-Fbg). The whole blood coagulation analyzer measured fibrinogen levels within 2 minutes. Strong correlations between standard-Fbg and whole blood-Fbg were observed (ρ = 0.91, p < 0.001). Error grid analysis showed that 88% of the values were clinically acceptable, and 12% were in a range with possible effects on clinical decision-making; none were in a clinically dangerous range without appropriate treatment. Using a fibrinogen cutoff value of 1.5 g/L for standard-Fbg, the area under the receiver operating characteristic curve of whole blood-Fbg was 0.980 (95% confidence interval 0.951-1.000, p < 0.001). The whole blood coagulation analyzer can rapidly measure fibrinogen levels in heparinized blood and could be useful in critical care settings where excessive bleeding is a concern.
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/61135/1/WB_fibrinogen_Text%20EJF.pdf

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