学術雑誌論文 Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian cells

Maruyama, Hideto  ,  Furukawa, Kazuhiro  ,  Kamiya, Hiroyuki  ,  Minakawa, Noriaki  ,  Matsuda, Akira

51 ( 37 )  , pp.7887 - 7890 , 2015-05-07 , Royal Society of Chemistry
ISSN:1359-7345
内容記述
Synthetic chemically modified nucleic acids, which are compatible with DNA/RNA polymerases, have great potential as a genetic material for synthetic biological studies. A comprehensive analysis of the transcription of 4'-thioDNA templates to natural RNA is herein reported. The modifications of DNA with 2'-deoxy-4'-thionucleosides, so-called 4'-thioDNA, were found to act as templates for transcription with RNA polymerases both in vitro and in mammalian cells.
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/60827/1/manuscript.pdf

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