学術雑誌論文 Cell Chirality Induces Collective Cell Migration in Epithelial Sheets

Sato, Katsuhiko  ,  Hiraiwa, Tetsuya  ,  Shibata, Tatsuo

115 ( 18 )  , pp.188102-1 - 188102-5 , 2015-10-30 , American Physical Society
ISSN:0031-9007
内容記述
During early development, epithelial cells form a monolayer sheet and migrate in a uniform direction. Here, we address how this collective migration can occur without breaking the cell-to-cell attachments. Repeated contraction and expansion of the cell-to-cell interfaces enables the cells to rearrange their positions autonomously within the sheet. We show that when the interface tension is strengthened in a direction that is tilted from the body axis, cell rearrangements occur in such a way that unidirectional movement is induced. We use a vertex model to demonstrate that such anisotropic tension can generate the unidirectional motion of cell sheets. Our results suggest that cell chirality facilitates collective cell migration during tissue morphogenesis.
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http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/60271/1/PhysRevLett.115.188102.pdf

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