紀要論文 Bevacizumab-induced tracheoesophageal fistula in a patient suffering from lung cancer with bulky subcarinal lymph node: a case report

Nishie, Kenichi  ,  Yasuo, Masanori  ,  Kitaguchi, Yoshiaki  ,  Kobayashi, Nobumitsu  ,  Tateishi, Kazunari  ,  Ushiki, Atsuhito  ,  Urushihata, Kazuhisa  ,  Yamamoto, Hiroshi  ,  Ideura, Gen  ,  Hanaoka, Masayuki

80 ( 1 )  , pp.129 - 134 , 2018-02 , Nagoya University Graduate School of Medicine, School of Medicine
ISSN:0027-7622
内容記述
A 66-year-old male with advanced non-small-cell lung cancer (NSCLC) who was previously treated with carboplatin, pemetrexed, and bevacizumab consequently suffered from severe coughing during degluti- tion. Chest computed tomography (CT) revealed a tracheoesophageal fistula (TEF) between the left main bronchus and esophagus through a subcarinal metastatic lymph node. Given the extreme swelling of the lymph node due to metastatic cancer, it was determined that the walls of the bronchus and esophagus had been injured simultaneously. Delayed and dysfunctional wound healing due to bevacizumab resulted in necrosis of the contact region leading to fistula formation. This case suggests that using bevacizumab for NSCLC in patients with bulky subcarinal lymphadenopathy may increase the risk for TEF.
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