Journal Article A Novel Apparatus for the Multifaceted Evaluation of Arterial Function Through Transmural Pressure Manipulation

Yaguchi, Toshiyuki  ,  Cong, Yalin  ,  Shimo, Kenji  ,  Kurokawa, Takahiro  ,  Sugita, Shukei  ,  Nagayama, Kazuaki  ,  Masuda, Hiroshi  ,  Matsumoto, Takeo

45 ( 6 )  , pp.1487 - 1495 , 2017-06 , Springer
A novel apparatus for the multifaceted evaluation of artery function was developed. It measures endothelial and smooth muscle functions and the pressure–strain elastic modulus (Ep). A rigid airtight chamber with an ultrasound probe was attached to the upper arm to manipulate the transmural pressure of the brachial artery. Endothelial function was measured via a standard flow-mediated dilation (FMD) protocol. Smooth muscle function was evaluated via a myogenic contraction of the artery following the application of negative pressure to the chamber and was named pressure-mediated contraction (PMC). Ep was obtained by measuring the instantaneous increase in the artery diameter following the negative pressure application. The PMC and FMD values had a significant negative correlation with age, indicating that the age-related decrease in FMD is caused by the decay of endothelial and smooth muscle function. A consideration of PMC may help improve the accuracy of artery function measurement. Ep in subjects aged >40 years was found to be significantly higher in the supra-physiological pressure range than in the physiological one (p = 0.02); this did not occur in younger subjects. Artery stiffening may begin in the supra-physiological range, and this stiffness may also be used for the diagnosis of atherosclerosis.

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