Journal Article A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives

Nakazaki, Atsuo  ,  Mori, Ayako  ,  Kobayashi, Susumu  ,  Nishikawa, Toshio

11 ( 22 )  , pp.3267 - 3274 , 2016-11-22 , Wiley
ISSN:1861-4728
Description
3,3-Disubstituted oxindoles were divergently synthesized by diastereoselective transformations including nucleophilic addition, alkylation, and cycloaddition using common, axially chiral N-aryl oxindoles. Notably, high diastereoselectivities (up to >95:5) were observed with ortho-monosubstituted N-aryl oxindoles to give various oxindole scaffolds, and facile removal of the p-(benzyloxy)aryl moiety in axially twisted amides was achieved by a mild, two-step sequence.
Full-Text

https://nagoya.repo.nii.ac.jp/?action=repository_action_common_download&item_id=23506&item_no=1&attribute_id=17&file_no=1

Number of accesses :  

Other information