紀要論文 ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men

Yin, Guang  ,  Naito, Mariko  ,  Wakai, Kenji  ,  Morita, Emi  ,  Kawai, Sayo  ,  Hamajima, Nobuyuki  ,  Suzuki, Sadao  ,  Kita, Yoshikuni  ,  Takezaki, Toshiro  ,  Tanaka, Keitaro  ,  Morita, Makiko  ,  Uemura, Hirokazu  ,  Ozaki, Etsuko  ,  Hosono, Satoyo  ,  Mikami, Haruo  ,  Kubo, Michiaki  ,  Tanaka, Hideo

78 ( 2 )  , pp.183 - 193 , 2016-05 , Nagoya University Graduate School of Medicine, School of Medicine
ISSN:0027-7622
内容記述
Associations between alcohol consumption and type 2 diabetes risk are inconsistent in epidemiologicstudies. This study investigated the associations of ADH1B and ALDH2 polymorphisms with fasting bloodglucose levels, and the impact of the associations of alcohol consumption with fasting blood glucose levelsin Japanese individuals. This cross-sectional study included 907 men and 912 women, aged 35–69 years.The subjects were selected from among the Japan Multi-institutional Collaborative Cohort study across sixareas of Japan. The ADH1B and ALDH2 polymorphisms were genotyped by Invader Assays. The ALDH2Glu504Lys genotypes were associated with different levels of fasting blood glucose in men (P = 0.04).Mean fasting glucose level was positively associated with alcohol consumption in men with the ALDH2504 Lys allele (Ptrend = 0.02), but not in men with the ALDH2 504Glu/Glu genotype (Ptrend = 0.45), resultingin no statistically significant interaction (P = 0.38). Alcohol consumption was associated with elevatedfasting blood glucose levels compared with non-consumers in men (Ptrend = 0.002). The ADH1B Arg48Hispolymorphism was not associated with FBG levels overall or after stratification for alcohol consumption.These findings suggest that the ALDH2 polymorphism is associated with different levels of fasting bloodglucose through alcohol consumption in Japanese men. The interaction of ALDH2 polymorphisms in theassociation between alcohol consumption and fasting blood glucose warrants further investigation.
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