Departmental Bulletin Paper Coagulation factors in whole blood collected from pregnant women and stored at 4°C

Minatoguchi, Miki  ,  Itakura, Atsuo  ,  Miki, Akinori  ,  Kajihara, Takeshi  ,  Sasaki, Shiho  ,  Takase, Yumiko  ,  Kobayashi, Kiyoko  ,  Asada, Rumiko  ,  Ikebuchi, Kenji  ,  Ishihara, Osamu

78 ( 1 )  , pp.1 - 7 , 2016-02 , Nagoya University Graduate School of Medicine, School of Medicine
The present study aimed to measure the levels of coagulation factors in stored whole blood of pregnant women and to determine their usefulness in treating pregnant women who developed coagulopathy. A prospective study to measure coagulation factors in stored donated whole blood from pregnant and non-pregnant women was conducted. Fibrinogen, FV, FVII, FVIII, FXIII, and von Willebrand factor were measured in blood stored at 4°C for 0, 1, 3, and 5 weeks. All coagulation factors except for factor XIII decreased during storage. Fibrinogen and factor VII in the blood collected from pregnant women gradually decreased over time and their levels were significantly higher after 5 weeks of storage than those of nonpregnant women at week 0. Whole blood donated by pregnant women for autologous blood transfusion and stored at 4°C may be expected being effectively for the prevention of coagulopathy and the treatment of circulatory blood volume loss.

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