Departmental Bulletin Paper Skull involvement in a pediatric case of chronic recurrent multifocal osteomyelitis

Watanabe, Toru  ,  Ono, Hiroyuki  ,  Morimoto, Yoshitaka  ,  Otsuki, Yoshiro  ,  Shirai, Masami  ,  Endoh, Akira  ,  Naito, Masaaki  ,  Inoue, Yoshiya  ,  Hongo, Teruaki

77 ( 3 )  , pp.493 - 500 , 2015-08 , Nagoya University Graduate School of Medicine, School of Medicine
An 11-year-old boy was diagnosed with chronic recurrent multifocal osteomyelitis (CRMO) and presented with right sacro-femoral and occipital lesions. Initially, a tumor was suspected. However, the bone biopsy showed osteomyelitis with a negative bacterial culture. Bone scintigraphy revealed inflammatory changes on multiple bone lesions. The slight elevation in inflammatory markers such as C-reactive protein was of little clinical value. He was diagnosed with CRMO by sacral biopsy, and the clinical course progressed, with the presence of a new occipital lesion observed after the 1-year follow-up. The administration of non-steroidal anti-inflammatory drugs successfully improved his clinical symptoms. The presence of a skull lesion in the occipital bone of a pediatric patient with CRMO has not been previously reported.

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