学術雑誌論文 油症における甲状腺機能の検討
Thyroid Function in Patients with Yusho

辻, 博  ,  蓮尾, 裕

108 ( 3 )  , pp.111 - 117 , 2017-03-25 , 福岡医学会
ISSN:0016-254X
NII書誌ID(NCID):AN00215478
内容記述
To investigate chronic effects of polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs) on thyroid functions, serum concentrations of thyroid stimulating hormone (TSH), triiodothyronine (T_3), thyroxine (T_4) and free T_4 were studied in serum of 197 patients with Yusho and 42 control subjects in 2015. Serum levels of T_3 were decreased in patients with Yusho compared with controls. A significant relationship between concentrations of PCB in the blood and serum levels of T_3 was observed, while there was no correlation between blood PCB concentrations and TSH, T_4 or free T_4 levels. Serum levels of T_3 were significantly decreased in the subjects with high PCB concentrations compared with those with low PCB concentrations. Furthermore, serum levels of T_3 were significantly decreased in the subjects with high 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) concentrations compared with those with low 2,3,4,7,8-PeCDF concentrations. We conclude that serum T_3 levels decrease in patients with Yusho, and it may be associated with PCBs and 2,3,4,7,8-PeCDF in the blood.
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https://catalog.lib.kyushu-u.ac.jp/opac_download_md/1810708/p111.pdf

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