||Safety Evaluation of Wood–Based Activated Carbon Fibers in a 28–day Feeding Study in Sprague–Dawley Rats
Lin, Han Chien ,
Hsueh, Ji Cheng ,
Li, Wen-Ru ,
Lai, Ying-Jang ,
Wu, She–ChingFujimoto, Noboru
434 , 2015-09-18 , Faculty of Agriculture, Kyushu University
As a possible food moisture–proof material, wood–based activated carbon fibers (WACFs), prepared from one type of wood pulp: Laubholz Unbleached Kraft Pulp (LUKP) by the physical activation method with steam at an 850°C activation temperature with 60min of activation time (850 LUKP WACFs), were evaluated in a 28–day feeding study of Sprague–Dawley rats (SD rats) after the Ames test had been carried out in a previous paper. SD rats were randomly distributed into five groups, including a blank group (reverse osmosis water), a control group (saline), and groups with low, moderate, and high (1.0, 2.5, and 5.0 g/kg/day, respectively) doses of 850 LUKP WACFs. All SD rats were sacrificed after a 28–day feeding toxicity study. Blood samples were analyzed for hematological and serum biochemical values, and histopathological examinations of the organs were investigated. There were insignificant differences from the clinical pathology; that is, no observable adverse effect levels (NOAEL) of 850 LUKP WACFs greater than 5.0 g/kg/day. It is suggested that WACFs prepared from wood pulp can be a potential type of food moisture–proof material and a potential type of material for water quality improvement due to their biological safety results.