学術雑誌論文 油症における抗SS-A/Ro抗体および抗SS-B/La抗体の検討
Anti-SSA/Ro and Anti-SSB/La Antibodies in Patients with Yusho

辻, 博

106 ( 5 )  , pp.119 - 123 , 2015-05-25 , 福岡医学会
ISSN:0016-254X
NII書誌ID(NCID):AN00215478
内容記述
To investigate chronic immune effects of polychlorinated biphenyl (PCB) and polychlorinated dibenzofuran (PCDF), anti-SSA/Ro and anti-SSB/La antibodies were studied in serum of 213 patients with Yusho and 63 control subjects in 2013. Anti-SSA/Ro antibodies were found in 4.2% (9/213) of patients with Yusho and 1.6% (1/63) of control subjects. The prevalence rates of anti-SSA/Ro antibodies in Yusho patients were not associated with blood PCB concentration or blood 2,3,4,7,8-pentachlorodibenzofuran (PeCDF) concentration. Anti-SSB/La antibodies were found in 1.4% (3/213) of patients of Yusho, but none of controls. Furthermore, high concentrations of PCB and 2,3,4,7,8-PeCDF were present in Yusho patients with anti-SSB/La antibodies. We conclude that anti-SSB/La antibody is present in patients with Yusho, and it may be associated with PCB and 2,3,4,7,8-PeCDF in the blood.
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http://catalog.lib.kyushu-u.ac.jp/handle/2324/1518354/p119.pdf

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